A history of mucosal necrosis and ulceration of the oral cavity and affected reticuloendothelial tissues was reported in a sheep farm. The virus-suspected samples were taken for possible isolation and inoculated into embryonated chicken eggs. After 72 hours of inoculation, death of embryo was  observed along with cherry red coloration. Identify the probable virus isolated? *

·         Caprine Encephalitis Arthritis virus

·         Bluetongue virus

·         Peste des petits ruminants virus

·         Foot and Mouth disease virus

Latency state of Alphaherpes viruses is found in______*                                                   

·         Sensory ganglia

·         Respiratory tract

·         Medulla oblongata

·         All the above

Which of the following is NOT TRUE with Avian Leukosis virus? *                                    

·         Intranuclear inclusion bodies can be demonstrated

·         Tumors extensively developed in liver, spleen and bursa

·         The viral nucleic acid integrates into host genome

·         Replication involves reverse transcription

Assertion: Infectious bursal disease virus and Blue tongue virus are classified under Baltimore group III Reason: Both viruses have double stranded RNA genome *

·         Both assertion and reason are wrong

·         Assertion is correct but reason is wrong

·         Assertion is wrong but reason is correct

·         Both assertion and reason are correct

Which of the following is TRUE with Foot and Mouth Disease? *                                      

·         In India commercially available vaccines are live attenuated vaccines

·         Both infection and vaccination induce sterile immunity

·         Annual vaccination of cattle is practised in India under the FMD-control program

·         Ring vaccination is used to control FMD when outbreak happens in particular location

Family of viruses that carry virion RNA dependent RNA polymerase? *                                

·         Picornaviridae

·         Parvoviridae

·         Flaviviridae

·         Paramyxoviridae

Number    of    serotypes    present    in    Blue    tongue    virus    and    foot    and    mouth disease virus respectively? *

·         28,3

·         27,7

·         29,7

·         26,3

Which of following is NOT a segmented virus? *                                                     

·         Birnavirus

·         Parvovirus

·         Bunyavirus

·         Reovirus

The genomic size following "rule of six” and ribonucleo protein complex in the viral inclusion bodies are characteristic of members of the Family:*

·         Pneumoviridae

·         Poxviridae

·         Paramyxoviridae

·         Filoviridae

Which of the following  chemicals are used as inactivating agent in killed vaccine preparation? *

·         Formaldehyde

·         Beta Propiolactone

·         Acetyl ethyleneimine

·         All the above

Following reports of birds exhibiting respiratory distress with swollen orbital sinus, tracheal swabs were taken and sent in cold chain for laboratory diagnosis of etiological agent. The virus-suspected samples were inoculated into embryonated chicken eggs through allantoic route. After 48 hrs of incubation, the embryos appeared as shown in the picture. What could be the possible causative agent suspected? *

·         Gallid Herpesvirus 1

·         Avibirnavirus

·         Avian coronavirus

·         Gallid Herpesvirus 2

Which of the following is NOT TRUE with morphology of viruses? *                                    

·         Most of the DNA virus nucleocapsids exhibit helical symmetry

·         Herringbone-shaped nucleocapsid is unique of Paramyxoviruses

·         Envelope of the virus is derived from host cell membrane

·         Filovirus virions appear as 6-shaped or U-shaped forms

Most of the RNA virus nucleocapsids exhibit helical symmetry

Which of the following virus involves arthropods as biological vector in its transmission? *

·         Eastern equine encephalitis virus

·         Bovine Ephemeral fever virus

·         Classical swine fever virus

·         Lumpy skin disease virus

Genetic reassortment between viruses resulting in antigenic changes and the emergence of a new variant, is termed as *

·         Reversion

·         Antigenic shift

·         Point mutation

·         Antigenic drift

Which of the following statement is TRUE with Rabies diagnostic tests? *                           

·         Real-Time PCR is highly sensitive but lacks specificity

·         Fluorescent Antibody Test is accepted for international trade

·         Fluorescent Antibody Virus Neutralization Test is accepted for international trade

·         It is easy to interpret the results of direct rapid Immuno chemistry test

Pseudorabies in dogs is caused by_________*                

·         Suid Herpesvirus

·         Bovine Herpesvirus

·         Bovine Herpesvirus

·         Gallid Herpesvirus

"Clock face” appearance of syncytia is observed in vero cells infected with________ *

·         Morbillivirus

·         Herpes virus

·         Reovirus

·         Pestivirus

Which of  the following vesicular disease affects cattle, small ruminants, swine and horse? *

·         Vesicular exanthema

·         Vesicular stomatitis

·         Foot and mouth disease

·         Swine vesicular disease

Assertion: Parvovirus affects dividing enterocytes Reason: Parvovirus require cells that are in mitotic phase for their DNA replication *

·         Assertion is correct but reason is wrong

·         Both assertion and reason are wrong

·         Assertion is wrong but reason is correct

·         Both assertion and reason are correct

Which of the following virus progenies existing within the cellular ribosome gives the appearance of "SAND” in electron microscopy? *

·         Arenavirus

·         Circovirus

·         Anellovirus

·         Bornavirus

Which of the following complement component has highest serum concentration? *

·         C4

·         C2

·         C3

·         C1q

Lesions shown in diagram are characteristic of infection in pigs *

·         Pestivirus C

·         Pestivirus D

·         Asfarvirus

·         Pestivirus A

The following antigens are considered as sequestered antigen except *                              

·         Myelin basic protein (MBP)

·         Lung tissue antigen

·         Sperm

·         Lens and corneal proteins of the eye

Immune unresponsiveness to an antigen induced by exposure of lymphocytes to antigen (Antigen specific) is called as? *

·         Immunosuppression

·         Auto immunity

·         Hyper sensitivity

·         Immunological tolerance

Which of following is TRUE with virus cultivation methods? *                                       

·         Primary cell cultures are less permissive to virus replication

·         Embryonated eggs can be used to cultivate all known viruses

·         Cell-lines are highly permissive than primary cell cultures to virus replication

·         Secondary cell cultures can be used to cultivate viruses up to 20 passages

The position 'ORDER'  in the virus classification system must have the suffix of________ *

·         viridae

·         virudae

·         virales

·         virinae

Which of the following autoantigen is targeted in systemic lupus erythematosus (SLE) autoimmune disease? *

·         Intracellular DNA

·         Red blood cells

·         Thyrotropin receptor

·         Acetylcholine receptors

A pet owner reported that his dog was showing signs of occasional abdominal pain. On clinical examination, petechial hemorrhages in oral mucosa  and bilateral corneal opacity were observed. Histopathology of liver  biopsy showed intranuclear inclusion bodies in Kupffer’s cells. Which of the following virus may be a probable etiological agent responsible for the above condition? *

·         Canine distemper virus

·         Canine parainfluenza virus

·         Canine parvovirus 2

·         Canine mastadenovirus A

Which of the following is NOT the feature of Orthomyxoviruses? *                                    

·         Nested transcription

·         Cap snatching

·         History of 'species-jumpers'

·         Antigenic drift

Which of the following is TRUE with foot and mouth disease? *                                      

·         Pig- Maintenance host; Cattle- Indicator host; Sheep and Goat- Amplifier host

·         Pig-Amplifier host; Cattle- Indicator host; Sheep and Goat-Maintenance host

·         Pig-Amplifier host; Cattle- Maintenance host; sheep and Goat- Indicator host

·         Pig- Indicator host; Cattle- Amplifier host; Sheep and Goat-Maintenance host

Foot-and-mouth disease virus is the type species of the Genus: Aphthovirus *

·         True

·         False

Fixed virus strain of Rabies refer to lab-adapted, low pathogenic and quickly replicating Rabies virus. *

·         False

·         True

Virulent strains of Newcastle disease virus have multiple basic residues at  the cleavage site. *

·         True

·         False

Rapidly transforming retroviruses are replication incompetent except Rous Sarcoma Virus. *

·         True

·         False

The name 'Reoviridae' is derived from members of this family i.e R-Rotavirus, E- Enterovirus, O-Orbivirus. *

·         True

·         False

Eclipse period of enveloped viruses is usually greater than non-enveloped viruses. *

·         False

·         True

Match the following *                                                                              

·         Retrovirus                          -  Baltimore group VI

·         Inclusion bodies of pox     -  Viroplasm

·         Hepadnavirus                    -   Baltimore group VII

·         Negribodies of Rabies       -  Viral nucelocapsids